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A carbohydrate vaccine exceeds the sum of its parts

Nature Chemical Biology volume 3, pages 605–606 (2007)Cite this article

A fully synthetic three-component vaccine has been shown to induce high titers of antibodies against the mucin Tn antigen of human cancer cells. The vaccine's superior properties are a result of the covalent incorporation of a ligand for Toll-like receptors and the presentation of the vaccine in a liposome format.

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Figure 1: The lipophilic Toll-like receptor (TLR) ligand locates the synthetic vaccine in the membrane of the liposome with the B epitope exposed to bind to the immunoglobulin receptor of a B cell.

Katie Ris-Vicari

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Authors and Affiliations

  1. David R. Bundle is in the Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada. dave.bundle@ualberta.ca,

    David R Bundle

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  1. David R Bundle
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Competing interests

D.R.B. receives funding to pursue research on topics related to the research described, and may act as a consultant to companies active in vaccine research and development.

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Bundle, D. A carbohydrate vaccine exceeds the sum of its parts. Nat Chem Biol 3, 605–606 (2007). https://doi.org/10.1038/nchembio1007-605

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