News and Views
Nature Chemical Biology 2, 451 - 452 (2006)
doi:10.1038/nchembio0906-451
A type III PKS makes the DIFference
Rajan Sankaranarayanan1
- Rajan Sankaranarayanan is a Wellcome Trust International Senior Research Fellow at the Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India. e-mail: sankar@ccmb.res.in
Abstract
Differentiation-inducing factor 1 is a modified polyketide natural product involved in the differentiation of Dictyostelium discoideum cells. A new study shows that a type III polyketide synthase existing in an unusual association with type I fatty acid synthase domains is responsible for biosynthesis of this signaling compound.
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