Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Discovery of a new 'dynasore'

Nature Chemical Biology volume 2, pages 355–356 (2006)Cite this article

Dynamin is a large GTPase that participates in the severing of membrane-bound vesicles. A small-molecule inhibitor specific for the dynamin family of GTPases has been identified and reveals new aspects of membrane dynamics.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Previously, methods such as siRNA and expression of dominant-negative dynamin have been used to test dynamin-mediated processes.

References

  1. Macia, E. et al. Dev. Cell 10, 839–850 (2006).

    Article  CAS  Google Scholar 

  2. Praefcke, G.J. & McMahon, H.T. Nat. Rev. Mol. Cell Biol. 5, 133–147 (2004).

    Article  CAS  Google Scholar 

  3. Hinshaw, J.E. Annu. Rev. Cell Dev. Biol. 16, 483–519 (2000).

    Article  CAS  Google Scholar 

  4. McNiven, M.A., Cao, H., Pitts, K.R. & Yoon, Y. Trends Biochem. Sci. 25, 115–120 (2000).

    Article  CAS  Google Scholar 

  5. Buccione, R., Orth, J.D. & McNiven, M.A. Nat. Rev. Mol. Cell Biol. 5, 647–657 (2004).

    Article  CAS  Google Scholar 

  6. Kruchten, A.E. & McNiven, M.A. J. Cell Sci. 119, 1683–1690 (2006).

    Article  CAS  Google Scholar 

  7. Thompson, H.M. & McNiven, M.A. Curr. Biol. 11, R850 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology and at the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, 55905, Minnesota, USA

    Heather M Thompson & Mark A McNiven

Authors
  1. Heather M Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark A McNiven
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thompson, H., McNiven, M. Discovery of a new 'dynasore'. Nat Chem Biol 2, 355–356 (2006). https://doi.org/10.1038/nchembio0706-355

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0706-355

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing