DNA-binding proteins accomplish the remarkable feat of finding their correct target sequences within a sea of genomic DNA. A new study uses NMR spectroscopy to show the mechanism by which proteins may hop between and slide along DNA as they search for their target binding sites.
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References
von Hippel, P.H. & Berg, O.G. J. Biol. Chem. 264, 675–678(1989).
Halford, S.E. & Marko, J.F. Nucleic Acids Res. 32, 3040–3052 (2004).
Winter, R.B., Berg, O.G. & von Hippel, P.H. Biochemistry 20, 6961–6977 (1981).
Iwahara, J. & Clore,G.M. Nature 440, 1227–1230 (2006).
Iwahara, J. & Clore,G.M. J. Am. Chem. Soc. 128, 404–405 (2006).
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Dahlquist, F. Slip sliding away: new insights into DNA-protein recognition. Nat Chem Biol 2, 353–354 (2006). https://doi.org/10.1038/nchembio0706-353
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DOI: https://doi.org/10.1038/nchembio0706-353
