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Letter
Nature Chemical Biology 2, 319–323 (1 June 2006) | doi:10.1038/nchembio792
Stochastic kinetics of intracellular huntingtin aggregate formation
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Abstract
Neurodegeneration in Huntington disease is described by neuronal loss in which the probability of cell death remains constant with time. However, the quantitative connection between the kinetics of cell death and the molecular mechanism initiating neurodegeneration remains unclear.
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