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Nature Chemical Biology 2, 297–298 (1 June 2006) | doi:10.1038/nchembio0606-297
Nucleation of huntingtin aggregation in cells
Abstract
The aggregation mechanisms of the polyglutamine-containing sequences relevant to Huntington disease and other expanded-CAG-repeat diseases are of continued great interest. In this issue of Nature Chemical Biology, Colby et al. describe an elegant analysis of the nucleation mechanism of aggregation for one such polyglutamine-rich fragment, the exon I fragment of huntingtin (httex1), as it takes place within a cell model.
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