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Nature Chemical Biology 2, 234–235 (1 May 2006) | doi:10.1038/nchembio0506-234

Redox sensing and histidine oxidation: no longer PerR-fect strangers

W Scott Moye-Rowley

Aerobic growth demands an ability to respond to the redox challenges that occur in an oxygen-rich environment. Detection of potentially toxic reactive oxygen species must be efficient and rapid for a cell to continuously monitor and adjust its intracellular oxidative balance.