Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments.
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References
Bonifacino, J.S. & Glick, B.S. Cell 116, 153–166 (2004).
Young, J.C., Agashe, V.R., Siegers, K. & Hartl, F.U. Nat. Rev. Mol. Cell Biol. 5, 781–791 (2004).
Onuchic, J.N. & Wolynes, P.G. Curr. Opin. Struct. Biol. 14, 70–75 (2004).
Huff, M.E., Page, L.J., Balch, W.E. & Kelly, J.W. Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type. J. Mol. Biol. 334, 119–127 (2003).
Sawkar, A.R. et al. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proc. Natl. Acad. Sci. USA 99, 15428–15433 (2002).
Albanese, V., Yam, A.Y., Baughman, J., Parnot, C. & Frydman, J. Cell 124, 75–88 (2006).
Young, J.C., Barral, J.M. & Ulrich Hartl, F. Trends Biochem. Sci. 28, 541–547 (2003).
Cohen, E., Bieschke, J., Perciavalle, R., Kelly, J.W. & Dillin, A. Science (in the press) (2006).
Gidalevitz, T., Ben-Zvi, A., Ho, K.H., Brignull, H.R. & Morimoto, R.I. Science 311, 1471–1474 (2006).
Morley, J.F. & Morimoto, R.I. Mol. Biol. Cell 15, 657–664 (2004).
Schroder, M. & Kaufman, R.J. Annu. Rev. Biochem. 74, 739–789 (2005).
Spiess, C., Meyer, A.S., Reissmann, S. & Frydman, J. Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets. Trends Cell Biol. 14, 598–604 (2004).
Lundbaek, J.A., Andersen, O.S., Werge, T. & Nielsen, C. Biophys. J. 84, 2080–2089 (2003).
Helenius, A. & Aebi, M. Annu. Rev. Biochem. 73, 1019–1049 (2004).
Allan, B.B. & Balch, W.E. Science 285, 63–66 (1999).
Storrie, B. Int. Rev. Cytol. 244, 69–94 (2005).
Kaeser, P.S. & Sudhof, T.C. Biochem. Soc. Trans. 33, 1345–1349 (2005).
Molinete, M., Irminger, J.C., Tooze, S.A. & Halban, P.A. Semin. Cell Dev. Biol. 11, 243–251 (2000).
Rorsman, P. & Renstrom, E. Diabetologia 46, 1029–1045 (2003).
Fowler, D.M. et al. PLoS Biol. 4, e6 (2006).
Conner, S.D. & Schmid, S.L. Nature 422, 37–44 (2003).
Hla, T. Prostaglandins Other Lipid Mediat. 77, 197–209 (2005).
Hill, S.J. Br. J. Pharmacol. 147 (Suppl 1.), S27–S37 (2006).
Aridor, M. & Balch, W.E. Nat. Med. 5, 745–751 (1999).
Moyer, B.D. & Balch, W.E. Expert Opin. Ther. Targets 5, 165–176 (2001).
Ulloa-Aguirre, A., Janovick, J.A., Brothers, S.P. & Conn, P.M. Traffic 5, 821–837 (2004).
Brady, R.O. Annu. Rev. Med. 57, 283–296 (2006).
Gadsby, D.C., Vergani, P. & Csanady, L. Nature 440, 477–483 (2006).
Lomas, D.A. et al. Biochem. Soc. Trans. 33, 321–330 (2005).
Buxbaum, J.N. & Tagoe, C.E. Annu. Rev. Med. 51, 543–569 (2000).
Sekijima, Y. et al. Cell 121, 73–85 (2005).
Sawkar, A.R. et al. Chem. Biol. 12, 1235–1244 (2005).
Pedemonte, N. et al. J. Clin. Invest. 115, 2564–2571 (2005).
Van Goor, F. et al. 2006. Am. J. Physiol. Lung Cell. Mol. Physiol., published online 27 January 2006 (doi:10.1152/ajplung.00169.2005).
Hammarstrom, P., Wiseman, R.L., Powers, E.T. & Kelly, J.W. Science 299, 713–716 (2003).
Saghatelian, A. & Cravatt, B.F. Global strategies to integrate the proteome and metabolome. Curr. Opin. Chem. Biol. 9, 62–68 (2005).
Acknowledgements
This work was supported by US National Institutes of Health grants GM42336 to W.E.B. and AG18917 and DK46335 to J.W.K. and by the Lita Annenberg Hazen Foundation (J.W.K.) and Cystic Fibrosis Foundation (W.E.B.).
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Kelly, J., Balch, W. The integration of cell and chemical biology in protein folding. Nat Chem Biol 2, 224–227 (2006). https://doi.org/10.1038/nchembio0506-224
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DOI: https://doi.org/10.1038/nchembio0506-224
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