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Nature Chemical Biology 2, 128–130 (1 March 2006) | doi:10.1038/nchembio0306-128
Watching single protons bind
Abstract
Many integral membrane proteins contain ionizable amino acids in their transmembrane domains. To understand the functional role of these protonatable side chains, the factors that determine the ionization state and the spread of the electrical potential through the protein interior must be elucidated.
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