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Commentary
Nature Chemical Biology 2, 55–58 (1 February 2006) | doi:10.1038/nchembio0206-55
Challenges facing the biologist doing chemical genetics
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Abstract
The use of small, cell-permeable compounds to dissect biological processes is referred to by some as chemical genetics, because these compounds often disrupt the function of a target protein in a manner analogous to a conditional mutation. This approach has been particularly useful for specifically inhibiting protein function in model systems that are not genetically tractable.
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