Chemically synthesizing complex oligosaccharides remains a significant challenge. Through the addition of hydrophobic appendages to 'unnatural' substrates, some oligosaccharide-forming glycosyltransferases can direct the formation of distinct sugar linkages while maintaining stereoselectivity.
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Griffith, B., Thorson, J. A sweet success for substrate engineering. Nat Chem Biol 2, 659–660 (2006). https://doi.org/10.1038/nchembio1206-659
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DOI: https://doi.org/10.1038/nchembio1206-659
