Perspective abstract
Nature Chemical Biology 2, 682 - 688 (2006)
doi:10.1038/nchembio843
Synthetic therapeutic antibodies
Sachdev S Sidhu1 & Frederic A Fellouse2
Abstract
Advances in selection technologies have sped up the process of generating antibodies with exquisitely tailored characteristics. In particular, synthetic antibody libraries, in which the antigen-binding sites are entirely man-made, have come of age and now rival or even exceed the potential of natural immune repertoires. Control over both library design and selection conditions enables unprecedented precision in antibody engineering. Synthetic libraries have been used to gain insights into the mechanisms of antibody structure and function, to tackle particularly difficult therapeutic challenges and to expand the utility of antibodies to novel areas of research.
- Sachdev S. Sidhu is in the Department of Protein Engineering, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
- Frederic A. Fellouse is at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Correspondence to: Sachdev S Sidhu1 e-mail: sidhu@gene.com
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Fluorescent proteins with ties that bindNature Biotechnology News and Views (01 Dec 2003)
Full-length antibodies on displayNature Biotechnology News and Views (01 May 2007)
See all 7 matches for News And ViewsRESEARCH
Recombining germline-derived CDR sequences for creating diverse single-framework antibody librariesNature Biotechnology Research (01 Aug 2000)
Selecting and screening recombinant antibody librariesNature Biotechnology Research (01 Sep 2005)
See all 59 matches for Research