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Solving an old puzzle in phospholipid biosynthesis

A new pathway involving a fatty acid intermediate for the initiation of membrane phospholipid synthesis has been identified. This finding answers the question of how most bacteria catalyze the first acylation step in phosphatidic acid formation.

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Figure 1: Initiation of phospholipid biosynthesis in bacteria.

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Schujman, G., de Mendoza, D. Solving an old puzzle in phospholipid biosynthesis. Nat Chem Biol 2, 573–574 (2006). https://doi.org/10.1038/nchembio1106-573

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  • DOI: https://doi.org/10.1038/nchembio1106-573

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