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S-nitrosylation TRiPs a calcium switch

Nature Chemical Biology volume 2, pages 570–571 (2006)Cite this article

Accumulating evidence indicates that protein S-nitrosylation may convey a broad spectrum of cellular signals. S-nitrosylation of critical cysteine thiols activates a subset of cation-permeable, transient receptor potential channel proteins (TRPs), which may represent a general mechanism for regulating stimulus-coupled cellular Ca2+ flux.

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Figure 1: An S-nitrosylation–based signaling module for eNOS.

Katie Ris

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Authors and Affiliations

  1. the Department of Medicine, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Matthew W Foster & Douglas T Hess

  2. the Department of Medicine and the Department of Biochemistry, Box 2612, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Jonathan S Stamler

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  1. Matthew W Foster
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  2. Douglas T Hess
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  3. Jonathan S Stamler
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Foster, M., Hess, D. & Stamler, J. S-nitrosylation TRiPs a calcium switch. Nat Chem Biol 2, 570–571 (2006). https://doi.org/10.1038/nchembio1106-570

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