Enzymatic cyclization of the linear polyketide chain to form a macrolactone is a key step in the biosynthesis of type I polyketide natural products. Structural biology and inhibitor design were used to gain insight into the mechanism and specificity of this enzymatic process.
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O'Connor, S. Cyclization of natural products. Nat Chem Biol 2, 511–512 (2006). https://doi.org/10.1038/nchembio1006-511
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DOI: https://doi.org/10.1038/nchembio1006-511
