A new small molecule inhibitor of TNF has an unexpected mechanism: it disrupts the trimeric structure of the protein.
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Clackson, T. Breaking and entering. Nat Chem Biol 2, 14–15 (2006). https://doi.org/10.1038/nchembio0106-14
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DOI: https://doi.org/10.1038/nchembio0106-14