Development of small-molecule agonists against members of the tumor necrosis factor (TNF) receptor superfamily remains a considerable challenge. Presentation of ligand-derived peptides on a trimeric scaffold may point the way toward development of potent small-molecule agonists against this biologically important protein superfamily.
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Hymowitz, S., Ashkenazi, A. Toward small-molecule agonists of TNF receptors. Nat Chem Biol 1, 353–354 (2005). https://doi.org/10.1038/nchembio1205-353
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DOI: https://doi.org/10.1038/nchembio1205-353
