Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Molecular motors: rocking and rolling

Kinesins are the molecular motors responsible for movement of vesicles inside cells. Evidence is now presented for how kinesin moves forward, as well as side to side.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A schematic diagram of the ATPase cycle in kinesin dimers (black) stepping on tubulin αβ-heterodimers (gray).

References

  1. Taniguchi, Y., Nishiyama, M., Ishii, Y. & Yanagida, T. Nat. Chem. Biol. 1, 342–347 (2005).

    Article  CAS  Google Scholar 

  2. Yajima, J. & Cross, R.A. Nat. Chem. Biol. 1, 338–341 (2005).

    Article  CAS  Google Scholar 

  3. Asbury, C.L. Curr. Opin. Cell Biol. 17, 89–97 (2005).

    Article  CAS  Google Scholar 

  4. Yildiz, A. & Selvin, P.R. Trends Cell Biol. 15, 112–120 (2005).

    Article  CAS  Google Scholar 

  5. Block, S.M. Cell 87, 151–157 (1996).

    Article  CAS  Google Scholar 

  6. Rice, S. et al. Biophys. J. 84, 1844–1854 (2003).

    Article  CAS  Google Scholar 

  7. Carter, N.J. & Cross, R.A. Nature 435, 308–312 (2005).

    Article  CAS  Google Scholar 

  8. Nitta, R., Kikkawa, M., Okada, Y. & Hirokawa, N. Science 305, 678–683 (2004).

    Article  CAS  Google Scholar 

  9. Endow, S.A. & Waligora, K.W. Science 281, 1200–1202 (1998).

    Article  CAS  Google Scholar 

  10. Hirose, K., Löwe, J., Alonso, M., Cross, R.A. & Amos, L.A. Mol. Biol. Cell 10, 2063–2074 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Amos, L. Molecular motors: rocking and rolling. Nat Chem Biol 1, 319–320 (2005). https://doi.org/10.1038/nchembio1105-319

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio1105-319

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing