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Letter
Nature Chemical Biology 1, 265–269 (1 October 2005) | doi:10.1038/nchembio731
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
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Abstract
Analyses of microbial genome sequences reveal numerous examples of gene clusters encoding proteins typically involved in complex natural product biosynthesis but not associated with the production of known natural products. In Streptomyces coelicolor M145 there are several gene clusters encoding new nonribosomal peptide synthetase (NRPS) systems not associated with known metabolites.
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