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Nature Chemical Biology 1, 244–245 (1 October 2005) | doi:10.1038/nchembio1005-244

Decoding chemical structures from genomes

Brian O Bachmann

Chance has always been a significant factor in the discovery of new natural-product structures. Typically, a large number of extracts must be fractionated, screened and partially characterized before a new natural product is isolated and characterized.