Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Decoding chemical structures from genomes

Coelichelin is a new tetrapeptide siderophore from Streptomyces coelicolor originally discovered by gene sequence analysis. Surprisingly, this tetrapeptide is assembled by a trimodular nonribosomal peptide synthetase.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A nonclassical nonribosomal peptide synthetase mechanism assembles coelichelin in S. coelicolor.

References

  1. Lautru, S., Deeth, R.J., Bailey, L.M. & Challis, G.L. Nat. Chem. Biol. 1, 265–269 (2005).

    Article  CAS  Google Scholar 

  2. Bentley, S.D. et al. Nature 417, 141–147 (2002).

    Article  Google Scholar 

  3. Sieber, S.A. & Marahiel, M.A. Chem. Rev. 105, 715–738 (2005).

    Article  CAS  Google Scholar 

  4. Challis, G.L. & Ravel, J. FEMS Microbiol. Lett. 187, 111–114 (2000).

    Article  CAS  Google Scholar 

  5. Challis, G.L., Ravel J., Townsend, C.A. Chem. Biol. 7, 211–224 (2000).

    Article  CAS  Google Scholar 

  6. Miao, V. et al. Microbiology 151, 1507–1523 (2005).

    Article  CAS  Google Scholar 

  7. McAlpine, J.B. et al. J. Nat. Prod. 68, 493–496 (2005).

    Article  CAS  Google Scholar 

  8. Van Regenmortel, M.H. EMBO Reports 5, 1016–1020 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bachmann, B. Decoding chemical structures from genomes. Nat Chem Biol 1, 244–245 (2005). https://doi.org/10.1038/nchembio1005-244

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio1005-244

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing