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Nature Chemical Biology 1, 186–187 (1 September 2005) | doi:10.1038/nchembio0905-186

Watching proteases in action

Klaudia Brix & Silvia Jordans

Genes encoding proteases within any genome are easily identified, and three-dimensional structures of many proteases have been solved. Most proteolytic cleavage mechanisms and protease substrate specificities have been established (the latter in some detail).