Blocking gene expression by interfering with translation of mRNA can be accomplished by means of antisense or short interfering RNA strategies, but more potent inhibitors would act by inhibiting transcription of genomic DNA. Two new studies show efficient inhibition of transcription using single-stranded peptide nucleic acid or double-stranded RNA targeted to the open complex formed at the transcription start site.
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Ann Thomson
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Armitage, B. Antigene leaps forward through an open door. Nat Chem Biol 1, 185–186 (2005). https://doi.org/10.1038/nchembio0905-185
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DOI: https://doi.org/10.1038/nchembio0905-185
