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Putting small molecules in the lead

Chemical genomic approaches offer an alternative to traditional high-throughput screening for drug discovery and provide an emerging approach to probing cellular biology. The 58th Ernst Schering Foundation Workshop on “Chemical Genomics: Small Molecule Probes to Study Cellular Function,” held April 6–8, 2005, in Berlin, Germany, captured recent chemical genomics advances and highlighted the power of a tight integration of chemistry and biology.

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Jaroch, S., Weinmann, H. Putting small molecules in the lead. Nat Chem Biol 1, 180–183 (2005). https://doi.org/10.1038/nchembio0905-180

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