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The Review summarized the recent progress in chemical probes and drug candidates for epigenetic writer enzymes and discussed the implication of targeting the chromatin regulatory landscape in cancer biology and therapy.
This Review surveys how resistance mutations to small molecules and recent mutagenesis technologies have driven biological discovery across diverse fields of inquiry.
Escherichia coli are a common component of the human microbiota, producing a diverse collection of small molecules that regulate intra- and interspecies interactions, including those with other microorganisms and with the host.
This Review article explores how uncovering phenotypes linked to the human microbiome often progresses from correlative studies to studies in germ-free animals and fecal microbiota transplants and, finally, to identification of strains and molecules.
Decades of research have identified the biochemical basis of many plant specialized metabolic pathways. This Review highlights the biological context of these pathways and how recent advances have extended the new frontiers of phytochemistry.
This Review highlights the latest progress on the molecular basis of metabolite signals in regulating aging and longevity, as well as state-of-the-art technological advances in studying bioactive metabolites.
A survey of natural metabolic pathways for C1 substrates (methane, methanol, carbon dioxide, and carbon monoxide) highlights past efforts and recent progress, and informs future opportunities to create synthetic C1-utilizing microbes.
This Review summarizes the recent technical advances in probing RNA secondary structures and discusses their connection with RNA regulatory functions in various biological processes and future directions in RNA structure-probing methods.
Cell–cell interactions and resulting signaling events drive key biological processes. This Review discusses the deconvolution of this complex biology through the development of tools for visualizing, chemically tagging and functionally exploiting these interactions.
This Review summarizes recent progress in small-molecule probes used to address questions in cell division and appraises some emerging techniques that can be adapted to cell division studies.
Autophagy has been widely implicated in human health and disease. The most recent advances in developing small molecule probes for autophagy are presented, as well as the potential to use this process for targeted protein degradation.
