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Nature Chemistry (19 December 2008) | doi:10.1038/nchem.106
Solid-supported synthesis: Analytical answer
Abstract
Solid-supported synthesis is the method of choice when preparing peptides, nucleic acids and libraries of closely related molecules. However, when attempting to transfer new chemistry to the solid phase, the major problem is the lack of a simple analytical technique that would allow the progress of reactions to be followed in real time.
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