Mechanical unfolding of a single DNA G-quadruplex structure with and without a stabilizing ligand can be used to calculate the binding strength of the ligand and could help to identify drugs to target these important biological assemblies.
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McCauley, M., Williams, M. Untying a nanoscale knot. Nature Chem 3, 754–755 (2011). https://doi.org/10.1038/nchem.1159
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DOI: https://doi.org/10.1038/nchem.1159
