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Volume 9 Issue 12, December 2007

A fluorescence image of two cortical neurons labelled for filamentous actin (red) and microtubules (green). The round cell on the left was transfected with a construct that sequesters Ena/VASP proteins to mitochondria (blue); this inhibits filopodia formation and neurite outgrowth.

Volume 9 Issue 12

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Editorial

  • Inspired by the visual spectacle cells offer under the microscope, some biologists have decided to put them on show.

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  • Collective cell invasion into the extracellular matrix (ECM) has been observed in malignant tumours and in tissue morphogenesis. To achieve this, leading cells trigger both proteolytic and structural modifications of the ECM to create channels that precede progressively widening chains of following cells.

    • Derek C. Radisky
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  • How is RNA Polymerase II (RNAP) regulated at poised loci in embryonic stem cells? Recent work provides new insights into Ring1-mediated transcriptional control of this important subset of developmental regulatory genes.

    • Tanya M. Spektor
    • Judd C. Rice
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  • Stem cells, and the microenvironment or 'niche' that influences them, must often reside in a particular location within a tissue to perform their function. Integrin-mediated adhesion is now shown to regulate the location of the stem-cell niche in the Drosophila testis.

    • Mark Van Doren
    News & Views
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