News and Views
Nature Cell Biology 9, 1229 - 1231 (2007)
doi:10.1038/ncb1107-1229
Fat or bone? A non-canonical decision
Thomas Günther1 & Roland Schüle1
-
Thomas Günther and Roland Schüle are at the Universitäts-Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany.
e-mail: roland.schuele@uniklinik-freiburg.de
Abstract
The transcription factor PPAR-
determines whether mesenchymal stem cells differentiate into adipocytes or osteoblasts. The finding that non-canonical Wnt signalling represses PPAR- through assembly of a nuclear corepressor complex containing the histone methyltransferase SETDB1 provides the first insight into how extracellular signals can regulate chromatin modification.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivationNature Cell Biology Article (01 Nov 2007)
DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxinInternational Journal of Obesity Scientific Correspondence
Tumour necrosis factor-α inhibits adipogenesis via a β-catenin/TCF4(TCF7L2)-dependent pathwayCell Death and Differentiation Original Article
