1. Keith Burridge and Renee Doughman are in the Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA. e-mail: Keith_Burridge@med.unc.edu

Abstract

The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (ROCK) provides a new basis for this crosstalk.

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