Nature Cell Biology 8, 631 - 639 (2006)
Published online: 14 May 2006; | doi:10.1038/ncb1415
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasisJung Hwa Kim1, Hee June Choi1, Bogyou Kim1, Mi Hyang Kim2, Ji Min Lee1, Ik Soo Kim1, Moon Hee Lee1, Soo Joon Choi1, Keun Il Kim3, Su-Il Kim2, Chin Ha Chung1
& Sung Hee Baek11
Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151–742, South Korea. 2
School of Agricultural Biotechnology, Seoul National University, Seoul 151–742, South Korea. 3
Department of Biological Sciences, Sookmyung Women's University, Seoul 140-742, South Korea.
Correspondence should be addressed to Sung Hee Baek sbaek@snu.ac.kr KAI1reptinHDAC1genesWntNF- B -cateninSENP1SUSP1Ubc9SENP2Defining the functional modules within transcriptional regulatory factors that govern switching between repression and activation events is a central issue in biology. Recently, we have reported the dynamic role of a -catenin–reptin chromatin remodelling complex in regulating a metastasis suppressor gene KAI1 (ref.1), which is capable of inhibiting the progression of tumour metastasis2,
3,
4,
5. Here, we identify signalling factors that confer repressive function on reptin and hence repress the expression of KAI1. Biochemical purification of a reptin-containing complex has revealed the presence of specific desumoylating enzymes that reverse the sumoylation of reptin that underlies its function as a repressor. Desumoylation of reptin alters the repressive function of reptin and its association with HDAC1. Furthermore, the sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential. These data clearly define a functional model and provide a novel link for SUMO modification in cancer metastasis.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated.
|
