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Survival choices

The recent discovery of many new mammalian DNA polymerases has left researchers trying to assign their biological functions. Surprising evidence has just emerged indicating that DNA polymerase κ, an enzyme implicated in the bypass of replication blocks, has a role in gap-filling synthesis during nucleotide excision repair (NER) of DNA adducts.

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Figure 1: Models for B and Y family polymerases in TLS and NER.

References

  1. Bebenek, K. & Kunkel, T. A. Adv. Protein Chem. 69, 137–165 (2004).

    Article  CAS  Google Scholar 

  2. Prakash, S., Johnson, R. E. & Prakash, L. Annu. Rev. Biochem. 74, 317–353 (2005).

    Article  CAS  Google Scholar 

  3. Ogi, T. & Lehmann, A. R. Nature Cell Biol. 8, 640–642 (2006).

    Article  CAS  Google Scholar 

  4. Friedberg, E. C. et al. in DNA Repair and Mutagenesis 2nd edn 317–326 (ASM Press, Washington D.C.. 2006).

    Google Scholar 

  5. Snyder, R. D., Van Houten, B. & Regan, J. D. Nucleic Acid Research Symposium Series 13, 13–33 (1984).

    CAS  Google Scholar 

  6. Ohashi, E. et al. J. Biol. Chem. 275, 39678–39684 (2000).

    Article  CAS  Google Scholar 

  7. Haracska, L. et al. Mol. Cell Biol. 22, 784–791 (2002).

    Article  CAS  Google Scholar 

  8. Ogi, T., Kannouche, P. & Lehmann, A. R. J. Cell Sci. 118, 129–136 (2005).

    Article  CAS  Google Scholar 

  9. Huang, T. T. et al. Nature Cell Biol. 8, 341–347 (2006).

    Article  Google Scholar 

  10. Abdulovic, A., Kim, N. & Jinks-Robertson, S. DNA Repair 5, 409–421 (2006).

    Article  CAS  Google Scholar 

  11. Nick McElhinny, S. A. & Ramsden, D. A. Immunol. Rev. 200, 156–164 (2004).

    Article  CAS  Google Scholar 

  12. Ohkumo, T., Masutani, C., Eki, T. & Hanaoka, F. Cell Struct. Funct. 31, 29–37 (2006).

    Article  CAS  Google Scholar 

  13. Gerlach, V. L . Feaver, W. J., Fischhaber, P. L. & Friedberg, E. C. J. Biol. Chem. 276, 92–98 (2001).

    Article  CAS  Google Scholar 

  14. Hakansson, P., Hofer, A. & Thelander, L. J. Biol. Chem. 281, 7834–7841 (2006).

    Article  CAS  Google Scholar 

  15. Sampath, D., Rao, V. A. & Plunkett, W. Oncogene 22, 9063–9074 (2003).

    Article  CAS  Google Scholar 

  16. Sarkar, S., Davies, A. A., Ulrich, H. D. & McHugh, P. J. EMBO J. 6, 1285–1294 (2006).

    Article  Google Scholar 

Download references

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Kunkel, T., Houten, B. Survival choices. Nat Cell Biol 8, 547–549 (2006). https://doi.org/10.1038/ncb0606-547

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