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Nature Cell Biology 8, 547 - 549 (2006)
doi:10.1038/ncb0606-547

Survival choices

Thomas A. Kunkel1 & Bennett Van Houten1

  1. Thomas A. Kunkel is in the Laboratory of Molecular Genetics and Laboratory of Structural Biology and Bennett Van Houten is in the Laboratory of Molecular Genetics at the National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. e-mail: kunkel@niehs.nih.gov


The recent discovery of many new mammalian DNA polymerases has left researchers trying to assign their biological functions. Surprising evidence has just emerged indicating that DNA polymerase kappa, an enzyme implicated in the bypass of replication blocks, has a role in gap-filling synthesis during nucleotide excision repair (NER) of DNA adducts.

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