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Nature Cell Biology 8, 308–310 (1 April 2006) | doi:10.1038/ncb0406-308

Chromosomes walk the line

Duane A. Compton

Accurate chromosome segregation is essential in cell division to ensure that aneuploidy is avoided, which causes birth defects and contributes to cancer initiation and progression. Chromosome segregation is mediated by a complex microtubule-based spindle.