Review abstract
Nature Cell Biology 8, 1195 - 1203 (2006)
doi:10.1038/ncb1497
Physicochemical modelling of cell signalling pathways
Bree B. Aldridge1,2, John M. Burke1, Douglas A. Lauffenburger1 & Peter K. Sorger1,2
Abstract
Physicochemical modelling of signal transduction links fundamental chemical and physical principles, prior knowledge about regulatory pathways, and experimental data of various types to create powerful tools for formalizing and extending traditional molecular and cellular biology.
- Bree B. Aldridge, John M. Burke, Douglas A. Lauffenburger and Peter K. Sorger are in the Center for Cell Decision Processes, Department Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
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Bree B. Aldridge and Peter K. Sorger are in the Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
e-mail: psorger@mit.edu
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