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An Apollon vista of death and destruction

Nature Cell Biology volume 6, pages 804–806 (2004)Cite this article

Proteins containing the BIR motif have been implicated as regulators of apoptosis and cell division. Apollon, an exceptionally large BIR-containing protein, inhibits apoptosis by targeting key cell death proteins for destruction by the ubiquitin-proteasome pathway. Now, deletion of apollon in the mouse has revealed a crucial function in cell division.

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Figure 1
Figure 2: A model for the regulation of apoptosis by Apollon.

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  1. Department of Genetics, Molecular Cell Biology Laboratory, The Smurfit Institute, Trinity College, Dublin, 2, Ireland

    Seamus J. Martin

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  1. Seamus J. Martin
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Martin, S. An Apollon vista of death and destruction. Nat Cell Biol 6, 804–806 (2004). https://doi.org/10.1038/ncb0904-804

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