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Unravelling Ras signals in cardiovascular disease

Nature Cell Biology volume 6, pages 807–808 (2004)Cite this article

The hyperplasia suppressor gene HSG, previously characterized for its function in mitochondrial fusion, has now been identified as a novel inhibitor of the Ras signalling pathway during smooth muscle cell proliferation. Because of the critical function of this process in atherosclerotic heart disease, these findings may have important clinical implications.

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Figure 1: Vascular smooth muscle cell (VSMC) proliferation and migration into the intima are key mechanisms of coronary artery restenosis.

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  1. the University of California San Diego Institute of Molecular Medicine, La Jolla, 92093, CA, USA

    Kenneth R. Chien & Masahiko Hoshijima

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  1. Kenneth R. Chien
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  2. Masahiko Hoshijima
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Chien, K., Hoshijima, M. Unravelling Ras signals in cardiovascular disease. Nat Cell Biol 6, 807–808 (2004). https://doi.org/10.1038/ncb0904-807

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