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Maintaining integrity

Nature Cell Biology volume 6, pages 923–928 (2004)Cite this article

Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.

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Figure 1: Early events in the cellular response to double-strand breaks (DSBs) in the DNA.
Figure 2: Real-time imaging of the recruitment of signalling and repair proteins to microlaser-generated sites of DNA damage.

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Authors and Affiliations

  1. Department of Human Genetics and Molecular Medicine, The David and Inez Myers Laboratory for Genetic Research, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Yosef Shiloh

  2. Genome Damage and Stability Centre, University of Sussex Falmer, Brighton, BN1 9RQ, UK

    Alan R. Lehmann

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  1. Yosef Shiloh
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  2. Alan R. Lehmann
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Correspondence to Yosef Shiloh or Alan R. Lehmann.

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Shiloh, Y., Lehmann, A. Maintaining integrity. Nat Cell Biol 6, 923–928 (2004). https://doi.org/10.1038/ncb1004-923

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