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Brief Communication
Nature Cell Biology 5, 1023–1025 (1 November 2003) | doi:10.1038/ncb1062
Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1
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Abstract
Disjunction of pairs of homologous chromosomes during the first meiotic division (MI) requires anaphase-promoting complex (APC)-mediated activation of separase in budding yeast and Caenorhabditis elegans, but not Xenopus laevis. It is not clear which model best fits the mammalian system.
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