During cell-contact-mediated repulsion, an initially adhesive interaction between a receptor and its ligand ultimately results in a repulsive response that causes the cells to separate. Two studies looking at the case of Eph receptors and ephrins now identify a crucial role for endocytosis in this enigmatic process.
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Wilkinson, D. How attraction turns to repulsion. Nat Cell Biol 5, 851–853 (2003). https://doi.org/10.1038/ncb1003-851
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DOI: https://doi.org/10.1038/ncb1003-851
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