News and Views


Nature Cell Biology 5, 851 - 853 (2003)
doi:10.1038/ncb1003-851

How attraction turns to repulsion

David G. Wilkinson1

  1. David G. Wilkinson is in the Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. e-mail: dwilkin@nimr.mrc.ac.uk


During cell-contact-mediated repulsion, an initially adhesive interaction between a receptor and its ligand ultimately results in a repulsive response that causes the cells to separate. Two studies looking at the case of Eph receptors and ephrins now identify a crucial role for endocytosis in this enigmatic process.

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