The establishment and maintenance of apicobasal cell polarity is of fundamental importance for most physiological functions of epithelial tissues. In Drosophila melanogaster, several critical regulators of cell polarity have been identified over the past years, but we are just beginning to understand how these genes interact with each other. Two new papers now shed light on the genetic hierarchy that rules this process.
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Johnson, K., Wodarz, A. A genetic hierarchy controlling cell polarity. Nat Cell Biol 5, 12–13 (2003). https://doi.org/10.1038/ncb0103-12
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DOI: https://doi.org/10.1038/ncb0103-12
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