 | Figure 1
Nature Cell Biology
4, E263 - E272 (2002)
doi:10.1038/ncb1102-e263
The cellular and molecular basis of store-operated calcium entryKartik Venkatachalam, Damian B. van Rossum, Randen L. Patterson, Hong-Tao Ma
& Donald L. Gill | | | | Figure 1. Coupling models for activation of store-operated channels (SOCs).
a, 'Chemical coupling', involving the release of a diffusible calcium influx factor (CIF) from the ER in response to release detected by a presumed luminal calcium sensor. b, 'Direct physical coupling', involving a direct interaction between components of the ER and PM, shown hypothetically as a complex between calcium release and entry channels. c, d, Two variations on the physical coupling theme. 'Induced coupling' (c), in which a dynamic process concomitant with store-depletion induces the formation of new conformationally coupled ER−PM junctions. d, 'Spatial coupling', in which a spatially close organization exists between ER and PM, permitting short-range signalling to effect SOC activation within a restricted space (shaded).
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