News and Views
Nature Cell Biology 4, E253 - E255 (2002)
doi:10.1038/ncb1102-e253
Integrins as developmental switches
Trent A. Watkins1 & Ben A. Barres1
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Trent Watkins and Ben Barres are in the Department of Neurobiology, Stanford University School of Medicine, Fairchild Building Room D235, 299 Campus Drive, Stanford, CA 94305-5125, USA
e-mail: trentw@stanford.edu
Abstract
Neuregulin (NRG) is a crucial regulator of oligodendrocyte development, strongly promoting both the proliferation of oligodendrocyte precursor cells and the survival and maturation of oligodendrocytes. How can the same growth factor mediate such different effects? New work in this issue of Nature Cell Biology implicates an integrin-mediated switch in signalling that results in the loss of the proliferative response and the enhancement of survival and maturation.
