Milestones in cell division - pE265

doi:10.1038/ncb1201-e265

Full Text - Milestones in cell division | PDF (271 KB) - Milestones in cell division

Welcome to the nucleus: CAN I take your coat? - ppE267 - E269

Amnon Harel & Douglass J. Forbes

doi:10.1038/ncb1201-e267

Individual viruses have evolved strategies for surmounting a formidable barrier in their path to replication in the nucleus — the nuclear envelope. A new study describing the nuclear entry of adenovirus 2 finds that this virus docks at the CAN/Nup214 protein of the nuclear pore, then hijacks histone H1 and specific H1-import receptors to effect a targeted uncoating of its nucleocapsid at the nuclear pore.

Full Text - Welcome to the nucleus: CAN I take your coat? | PDF (1,034 KB) - Welcome to the nucleus: CAN I take your coat?

See also: Article by Trotman et al.

Mitochondrial fission in life and death - pE269

Valerie Ferrier

doi:10.1038/ncb1201-e269

Full Text - Mitochondrial fission in life and death | PDF (589 KB) - Mitochondrial fission in life and death

Deconstructing desmoplakin - ppE270 - E272

Sarah Hatsell & Pamela Cowin

doi:10.1038/ncb1201-e270

Mature desmosomes are the main adhesive junctions in epithelia and cardiac muscle. Now new work shows that the desmosomal protein desmoplakin is also essential for the maturation of adherens junctions. Desmoplakin clamps down on the transient zippering courtship of the classical cadherins, promoting the maturation of puncta adherens junctions and cortical actin remodelling, steps that are essential for cell adhesion.

Full Text - Deconstructing desmoplakin | PDF (747 KB) - Deconstructing desmoplakin

See also: Article by Vasioukhin et al.

Natural sunscreen revealed - pE272

Saquib Lakhani & Richard A. Flavell

doi:10.1038/ncb1201-e272

Full Text - Natural sunscreen revealed | PDF (155 KB) - Natural sunscreen revealed

The nuclear envelope: filling in gaps - ppE273 - E274

Brian Burke

doi:10.1038/ncb1201-e273

Mitosis in higher organisms requires the dismantling of the nucleus. Reforming the nucleus at the end of mitosis involves the targeting of membranes to chromatin surfaces, followed by fusion to create a closed nuclear envelope. Recent work has identified some of the key players in this fusion process.

Full Text - The nuclear envelope: filling in gaps | PDF (306 KB) - The nuclear envelope: filling in gaps

See also: Article by Hetzer et al.

Inflamed brains and the demented elderly - pE275

Pim van Gool reviews Neuroinflammatory Mechanisms in Alzheimer's Disease: Basic and Clinical Research by J. Rodgers

doi:10.1038/ncb1201-e275

Full Text - Inflamed brains and the demented elderly | PDF (295 KB) - Inflamed brains and the demented elderly

What is left in the 'post-genome' era? - pE276

Heiko Hermeking reviews Regulation of Gene Expression by K. E. Chapman & S. J. Higgins

doi:10.1038/ncb1201-e276

Full Text - What is left in the 'post-genome' era? | PDF (305 KB) - What is left in the 'post-genome' era?

The evolution of diverse biological responses to DNA damage: insights from yeast and p53 - ppE277 - E286

Geoffrey M. Wahl & Antony M. Carr

doi:10.1038/ncb1201-e277

Abstract - | Full Text - The evolution of diverse biological responses to DNA damage: insights from yeast and p53 | PDF (399 KB) - The evolution of diverse biological responses to DNA damage: insights from yeast and p53

Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1 - pp1035 - 1042

Oliver Ullrich, Antje Diestel, Ilker Y. Eyüpoglu & Robert Nitsch

doi:10.1038/ncb1201-1035

Abstract - | Full Text - Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1 | PDF (858 KB) - Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1

Feedback regulation of the MBF transcription factor by cyclin Cig2 - pp1043 - 1050

José Ayté, Colleen Schweitzer, Patrick Zarzov, Paul Nurse & James A. DeCaprio

doi:10.1038/ncb1201-1043

Abstract - | Full Text - Feedback regulation of the MBF transcription factor by cyclin Cig2 | PDF (827 KB) - Feedback regulation of the MBF transcription factor by cyclin Cig2 | Supplementary information

MAP kinase dynamics in response to pheromones in budding yeast - pp1051 - 1059

Frank van Drogen, Volker M. Stucke, Gerda Jorritsma & Matthias Peter

doi:10.1038/ncb1201-1051

Abstract - | Full Text - MAP kinase dynamics in response to pheromones in budding yeast | PDF (741 KB) - MAP kinase dynamics in response to pheromones in budding yeast | Supplementary information

Increased filamin binding to -integrin cytoplasmic domains inhibits cell migration - pp1060 - 1068

David A. Calderwood, Anna Huttenlocher, William B. Kiosses, David M. Rose, Darren G. Woodside, Martin A. Schwartz & Mark H. Ginsberg

doi:10.1038/ncb1201-1060

Abstract - | Full Text - Increased filamin binding to -integrin cytoplasmic domains inhibits cell migration | PDF (1,002 KB) - Increased filamin binding to -integrin cytoplasmic domains inhibits cell migration | Supplementary information

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization - pp1069 - 1075

Quansheng Du, P. Todd Stukenberg & Ian G. Macara

doi:10.1038/ncb1201-1069

Abstract - | Full Text - A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization | PDF (1,525 KB) - A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization | Supplementary information

Desmoplakin is essential in epidermal sheet formation - pp1076 - 1085

Valeri Vasioukhin, Ethan Bowers, Christoph Bauer, Linda Degenstein & Elaine Fuchs

doi:10.1038/ncb1201-1076

Abstract - | Full Text - Desmoplakin is essential in epidermal sheet formation | PDF (5,755 KB) - Desmoplakin is essential in epidermal sheet formation

See also: News and Views by Hatsell & Cowin

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly - pp1086 - 1091

Martin Hetzer, Hemmo H. Meyer, Tobias C. Walther, Daniel Bilbao-Cortes, Graham Warren & Iain W. Mattaj

doi:10.1038/ncb1201-1086

Abstract - | Full Text - Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly | PDF (1,772 KB) - Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly | Supplementary information

See also: News and Views by Burke

Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1 - pp1092 - 1100

Lloyd C. Trotman, Nicole Mosberger, Maarten Fornerod, Robert P. Stidwill & Urs F. Greber

doi:10.1038/ncb1201-1092

Abstract - | Full Text - Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1 | PDF (3,719 KB) - Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1 | Supplementary information

See also: News and Views by Harel & Forbes

The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment - pp1101 - 1113

Pierfrancesco Marra, Tania Maffucci, Tiziana Daniele, Giuseppe Di Tullio, Yukio Ikehara, Edward K. L. Chan, Alberto Luini, Gala Beznoussenko, Alexander Mironov & Maria Antonietta De Matteis

doi:10.1038/ncb1201-1101

Abstract - | Full Text - The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment | PDF (8,969 KB) - The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment | Supplementary information

Design and application of a cytokine-receptor-based interaction trap - pp1114 - 1119

Sven Eyckerman, Annick Verhee, José Van der Heyden, Irma Lemmens, Xaveer Van Ostade, Joël Vandekerckhove & Jan Tavernier

doi:10.1038/ncb1201-1114

Abstract - | Full Text - Design and application of a cytokine-receptor-based interaction trap | PDF (397 KB) - Design and application of a cytokine-receptor-based interaction trap | Supplementary information

Differential contribution of cytoplasmic Ca²⁺ and Ca²⁺ influx to gamete fusion and egg activation in maize - pp1120 - 1123

Anne-Frédérique Antoine, Jean-Emmanuel Faure, Christian Dumas & José A. Feijó

doi:10.1038/ncb1201-1120

Abstract - | Full Text - Differential contribution of cytoplasmic Ca2+ and Ca2+ influx to gamete fusion and egg activation in maize | PDF (535 KB) - Differential contribution of cytoplasmic Ca2+ and Ca2+ influx to gamete fusion and egg activation in maize

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling - pp1124 - 1128

Thierry Virolle, Eileen D. Adamson, Veronique Baron, Diana Birle, Dan Mercola, Tomas Mustelin & Ian de Belle

doi:10.1038/ncb1201-1124

Abstract - | Full Text - The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling | PDF (576 KB) - The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila - pp1129 - 1132

Hui-Min Chung & Gary Struhl

doi:10.1038/ncb1201-1129

Abstract - | Full Text - Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila | PDF (3,273 KB) - Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila