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FBXW5 controls centrosome number

Nature Cell Biology volume 13, pages 888–890 (2011)Cite this article

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Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.

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Figure 1: Positive regulators of centriole duplication are regulated by degradation.

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Authors and Affiliations

  1. Julia Pagan and Michele Pagano are in the Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA,

    Julia Pagan & Michele Pagano

  2. Michele Pagano is at the Howard Hughes Medical Institute, 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789, USA,

    Michele Pagano

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  1. Julia Pagan
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Correspondence to Michele Pagano.

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The authors declare no competing financial interests.

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Pagan, J., Pagano, M. FBXW5 controls centrosome number. Nat Cell Biol 13, 888–890 (2011). https://doi.org/10.1038/ncb2312

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