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SAD kinase keeps centrosomes lonely

Centrosome duplication is under strict control such that it occurs only once per cell cycle. New insights into the molecular mechanisms that control centrosome number come from the discovery of a role for SADB kinase in centrosome biogenesis.

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Figure 1: A unifying model for the control of centrosome duplication and its coordination with DNA replication in mammalian cells.

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Chen, D., Vogel, J. SAD kinase keeps centrosomes lonely. Nat Cell Biol 11, 1047–1048 (2009). https://doi.org/10.1038/ncb0909-1047

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