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Nature Cell Biology 11, 235 - 236 (2009)
doi:10.1038/ncb0309-235
Prions tunnel between cells
Hans-Hermann Gerdes1
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Hans-Hermann Gerdes is in the Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
e-mail: hans-hermann.gerdes@biomed.uib.no
Abstract
Prions are abnormal isoforms of host proteins that are the infectious agents in certain mammalian neurodegenerative diseases. How prions travel from their peripheral entry sites to the brain where they cause disease is poorly understood. A new study finds that tunnelling nanotubes are important for the intercellular transfer of prions during neuroinvasion.
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