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Correspondence

Nature Cell Biology 11, 1275–1276 (1 November 2009) | doi:10.1038/ncb1109-1275

Cyclin-dependent kinases: a family portrait

Marcos Malumbres , Edward Harlow , Tim Hunt , Tony Hunter , Jill M. Lahti , Gerard Manning , David O. Morgan , Li-Huei Tsai & Debra J. Wolgemuth

To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of proteins known as CDK-like (CDKL) kinases.