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Nature Cell Biology 10, 1021–1023 (1 September 2008) | doi:10.1038/ncb0908-1021
Twisted epithelial|[ndash]|mesenchymal transition blocks senescence
Abstract
EMT programs operate in several key steps of embryonic morphogenesis, enabling epithelial cells to acquire mesenchymal properties. Cancer cells appropriate and exploit these programs to acquire phenotypes associated with high-grade malignancy — the abilities to invade and metastasize.
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