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Letter
Nature Cell Biology 10, 740–747 (1 June 2008) | doi:10.1038/ncb1737
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
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Abstract
The growth and metabolic actions of growth hormone (GH) are believed to be mediated through the GH receptor (GHR) by JAK2 activation. The GHR exists as a constitutive homodimer, with signal transduction by ligand-induced realignment of receptor subunits.
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