News and Views
Nature Cell Biology 10, 637 - 639 (2008)
doi:10.1038/ncb0608-637
p53: The Janus of autophagy?
-
Beth Levine is in the Departments of Internal Medicine and Microbiology at the University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
e-mail: beth.levine@utsouthwestern.edu -
John Abrams is in the Department of Cell Biology at the University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
e-mail: john.abrams@utsouthwestern.edu
Abstract
The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Control of autophagy initiation by phosphoinositide 3-phosphatase jumpyThe EMBO Journal Article (05 Aug 2009)
Modulation of intracellular ROS levels by TIGAR controls autophagyThe EMBO Journal Article (07 Oct 2009)
