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Letter

Nature Cell Biology 10, 429–436 (1 April 2008) | doi:10.1038/ncb1705

Tensile forces govern germ-layer organization in zebrafish

M. Krieg , Y. Arboleda-Estudillo , P.-H. Puech , J. K|[auml]|fer , F. Graner , D. J. M|[uuml]|ller & C.-P. Heisenberg

Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells.